Ruolo dell’insulina e del recettore insulinico nel tessuto adiposo

Role of insulin and insulin receptor in adipose tissue

Insulin regulates whole-body energy and lipid metabolism by activating the insulin receptor (INSR) consisting in two isoforms: INSR-A expressed in less-differentiated cells with prominent mitogenic effect; INSR-B mostly expressed in adult tissues with pronounced metabolic properties. It is well known that tissue-specific variation in INSR-A/INSR-B ratio may favour the development of metabolic abnormalities. Herein, we examine the role of insulin/INSR signalling in the regulation of several aspects of adipose tissue physiology and the effects of insulin mimetics on adiposity.