Ruolo dell’insulina e del recettore insulinico nel tessuto adiposo

Role of insulin and insulin receptor in adipose tissue

Insulin regulates whole-body energy and lipid metabolism by activating the insulin receptor (INSR) consisting in two isoforms: INSR-A expressed in less-differentiated cells with prominent mitogenic effect; INSR-B mostly expressed in adult tissues with pronounced metabolic properties. It is well known that tissue-specific variation in INSR-A/INSR-B ratio may favour the development of metabolic abnormalities. Herein, we examine the role of insulin/INSR signalling in the regulation of several aspects of adipose tissue physiology and the effects of insulin mimetics on adiposity.

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Il Diabete Online, Organo ufficiale della Società Italiana di Diabetologia, Medicina Traslazionale, Vol. 35 n. 2 luglio 2023

DOI: https://doi.org/10.30682/ildia2302g

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Genchi, V. A., Lauriola, C., Cignarelli, A., & Giorgino, F. (2023). Ruolo dell’insulina e del recettore insulinico nel tessuto adiposo. Il Diabete, 35(2). https://doi.org/10.30682/ildia2302g

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This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published online: 10 Luglio 2023