Il ruolo dei progenitori delle cellule endoteliali nel diabete mellito

The role of endotelial progenitor cells in diabetes mellitus

Diabetes is associated with increased risk of cardiovascular morbidity and mortality. Endothelial progenitor cells (EPCs) are bone marrow-derived cells involved in endothelial health, vasculogenesis and damage repair. Both subjects with type 1 and type 2 diabetes showed a lower number of EPCs and impaired EPC function, suggesting a potential pathogenic role of these cells in both micro and macrovascular complications, as well as in sexual dysfunctions in diabetes. Several glucose-lowering drugs have been reported to potentially improve EPCs levels and bioreactivity. However, larger and longer studies are needed to better explain the mechanisms involved.