Update sulla malattia renale diabetica (DKD): focus sulla DKD non albuminurica e il rischio cardiovascolare

Non-albuminuric DKD phenotype: a breakthrough in DKD classic conception

The classic description of diabetic kidney disease (DKD) involves progressive stages of glomerular hyperfiltration, microalbuminuria, and a decline in the estimated glomerular filtration rate (eGFR). However, large studies have revealed that eGFR decline may also occur independently from development of albuminuria. This concept led to the identification of a new phenotype: non-albuminuric DKD, whose pathogenesis is still unknown and data in literature are still controversial. This review is focused on cardiovascular risk profile and therapeutical implication of this new DKD phenotype.