Lipodistrofie: quando magro non è sinonimo di metabolicamente sano

Lipodystrophies: when thin is not synonymous of being metabolically healthy

Lipodystrophy syndromes are rare, heterogeneous disorders with significant health impacts, compromising quality of life. Characterized by complete or partial adipose tissue deficiency, either congenital or acquired, they are often associated with low serum leptin levels and severe metabolic abnormalities like diabetes mellitus and dyslipidemia. Diagnosis is challenging due to phenotypic variability and low prevalence. Management requires a multidisciplinary approach, including lifestyle changes and may necessitate leptin replacement therapy.