Indicazioni cliniche sull’uso della metformina in gravidanza e nel periodo periconcezionale

The aim of this editorial is to give some practical guidance drawn from the evidence-based literature on the use of metformin in pregnancy and in the periconceptional period for different health conditions, such as overweight and obesity, gestational diabetes, type 2 diabetes mellitus, polycystic ovary syndrome and in women undergoing assisted reproductive technology. Metformin use in pregnancy is still a controversial topic particularly because it can cross the human placenta. Therefore, caution is needed since many long-term effects on the offspring of mothers treated with metformin during pregnancy are not yet fully known.